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Rescue of the murine sarcoma virus genome from non-producer cells by the RD-114 type C virus

✍ Scribed by R. V. Gilden; Y. K. Lee; C. Long

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
447 KB
Volume
10
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

A pseudotype focus‐forming virus was prepared by fusion of human cells infected with RD‐114 virus and non‐producer hamster cells transformed by murine sarcoma virus. The focus‐forming virus, designated MSV (RD‐114), transformed human fibroblasts, including WI‐38, but no mouse, hamster, or rat embryo cells. MSV (RD‐114) possesses envelope, group‐specific, and polymerase antigenic reactivities characteristic of RD‐114 virus. RD‐114 infected cells were resistant to focus formation by MSV (RD‐114) while no diminution in focus‐forming activity was observed in cells infected with feline leukemia virus.

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