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Rescue of beta-cell exhaustion by diazoxide after the development of diabetes mellitus in rats with streptozotocin-induced diabetes

✍ Scribed by Masafumi Matsuda; Fumiko Kawasaki; Yoshiki Mikami; Yasuo Takeuchi; Mieko Saito; Masaaki Eto; Kohei Kaku

Book ID
114015112
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
474 KB
Volume
453
Category
Article
ISSN
0014-2999

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## Abstract The pharmacokinetic parameters of 5‐fluorouracil were compared after intravenous administration at a dose of 30 mg/kg to control Sprague–Dawley rats and to rats with diabetes mellitus induced by streptozotocin (DMIS). In DMIS rats, the area under the plasma concentration–time curve from