For cross-presentation immature dendritic cells (DC) require enhanced antigen (Ag) uptake and a maturation signal to prime for MHC class I-restricted CTL responses in vivo. While immunostimulatory CpG-DNA provides, via TLR9, the maturation signal, CpG-DNA linked to Ag augments cellular Ag uptake. In
Rescue of B cells from apoptosis by immune stimulatory CpG DNA
β Scribed by Krieg, Arthur M. ;Yi, Ae-Kyung
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 513 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0344-4325
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Expression of a 32-kDa ligand for the CD40 antigen on activated human T lymphocytes To identify the ligand(s) of the human CD40 antigen, a cDNA encoding the extracellular domain of the CD40 antigen was fused to a cDNA encoding the constant region (Fc) of human IgG1. The CD40-Fc fusion protein w
The human Burkitt lymphoma Ramos B cell line can be induced to undergo apoptosis in response to a variety of different agents, including calcium ionophores, anti-immunoglobulin (lg) and macromolecular synthesis inhibitors. In addition, following up-regulation of the Fas (CD95) surface receptor by CD