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Requirements for reliable determination of binding affinity constants by saturation analysis approach

โœ Scribed by Jean-Louis Borgna


Book ID
116697462
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
453 KB
Volume
92
Category
Article
ISSN
0960-0760

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## Abstract One of the biggest challenges in the โ€œ__in silico__โ€ screening of enzyme ligands is to have a protocol that could predict the ligand binding free energies. In our group we have developed a very simple screening function (referred to as solvent accessibility free energy of binding predic