Requirement of SpOtx in Cell Fate Decisions in the Sea Urchin Embryo and Possible Role as a Mediator of β-Catenin Signaling

Nuclear β-catenin-dependent Wnt8 signali

Nuclear β-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages

✍ Athula H. Wikramanayake; Robert Peterson; Jing Chen; Ling Huang; Joanna M. Bince 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 576 KB

## Abstract The entry of β‐catenin into vegetal cell nuclei beginning at the 16‐cell stage is one of the earliest known molecular asymmetries seen along the animal–vegetal axis in the sea urchin embryo. Nuclear β‐catenin activates a vegetal signaling cascade that mediates micromere specification an