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Requirement for p53 and p21 to Sustain G2 Arrest After DNA Damage

✍ Scribed by Bunz, F.

Book ID: 121160302
Publisher: American Association for the Advancement of Science
Year: 1998
Tongue: English
Weight: 426 KB
Volume: 282
Category: Article
ISSN: 0036-8075
DOI: 10.1126/science.282.5393.1497

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p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we sh