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Requirement for matching T cell and B cell subsets in secondary anti-hapten antibody responses

✍ Scribed by R. M. Gorczynski; A. J. Cunningham

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
277 KB
Volume
8
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

The in vitro secondary anti‐hapten response to trinitrophenylated keyhole limpet hemocyanin (TNP‐KLH) has been investigated using B and T cells from the same or a pool of identically primed syngeneic individuals. The optimum antibody response obtained from B cells of any given animal was seen when the same individual's T cells were used as a helper cell source. This individual preference was lost if secondary challenge in culture was made with TNP on a heterologous carrier, with the helper cells obtained from suitably primed individuals or a pool thereof. These data are interpreted in terms of a network theory for the regulation of immune responses under physiological conditions.

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