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Requirement for HIV-1 TAR sequences for Tat activation in rodent cells

โœ Scribed by Julia A. Sutton; Martin Braddock; Alan J. Kingsman; Susan M. Kingsman

Book ID
114093670
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
792 KB
Volume
206
Category
Article
ISSN
0042-6822

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Tat-mediated activation of the HIV-1 promoter activity requires Tat-dependent recruitment of the cyclinT1/CDK9 complex (P-TEFb) to the transacting element (TAR) RNA. Tat interaction with the cyclinT1, the regulatory partner of CDK9, results in a speciยฎc recruitment of the heterodimer CycT1/CDK9 comp