Requirement for Croquemort in Phagocytosis of Apoptotic Cells in Drosophila

✍ Scribed by Franc, N. C.

• Book ID: 121161175
• Publisher: American Association for the Advancement of Science
• Year: 1999
• Tongue: English
• Weight: 588 KB
• Volume: 284
• Category: Article
• ISSN: 0036-8075
• DOI: 10.1126/science.284.5422.1991

✦ Synopsis

Macrophages in the
Drosophila
embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that
crq
was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in
Drosophila
.