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Requirement for cGMP in Nerve Cell Death Caused by Glutathione Depletion

โœ Scribed by Yonghong Li, Pamela Maher and David Schubert

Book ID
124810102
Publisher
Rockefeller University Press.
Year
1997
Tongue
English
Weight
433 KB
Volume
139
Category
Article
ISSN
0021-9525

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## Abstract Naphthalene is metabolized in the lung and liver to reactive intermediates by cytochrome P450 enzymes. These reactive species deplete glutathione, covalently bind to proteins, and cause necrosis in Clara cells of the lung. The importance of glutathione loss in naphthalene toxicity was i