✦ LIBER ✦

Reproductive factors and exogenous hormone use and risk of adult glioma in women in the NIH-AARP Diet and Health Study

✍ Scribed by Geoffrey C. Kabat; Yikyung Park; Albert R. Hollenbeck; Arthur Schatzkin; Thomas E. Rohan

Publisher: John Wiley and Sons
Year: 2010
Tongue: French
Weight: 138 KB
Volume: 128
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.25413

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Experimental evidence suggests that estrogen and other steroid hormones may protect against glioma. Although epidemiologic studies provide only weak support for a role of exogenous or endogenous hormones in gliogenesis, few cohort studies have addressed this question. The authors, therefore, examined the association between menstrual and reproductive factors, exogenous hormone use, and glioma risk among 225,355 women aged 50–71 years who completed the baseline questionnaire in the NIH‐AARP Diet and Health Study. During 7.5 years of follow‐up, 174 cases of incident, primary glioma were ascertained. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for exposures, taking potential confounders into account. Older age at menarche was positively associated with risk: HR 1.67 (95% CI: 1.03, 2.69). Other reproductive factors, including age at first live birth, parity, age at menopause, type of menopause (natural vs. medical) and exogenous hormone use showed no association with glioma risk. The results were similar when the analysis was restricted to cases with glioblastoma (N = 130). The present study provides only limited support for the hypothesis that menstrual/reproductive factors or exogenous hormone use play a role in gliogenesis.

📜 SIMILAR VOLUMES

Reproductive factors, exogenous hormone

Reproductive factors, exogenous hormone use and risk of lymphoid neoplasms among women in the National Institutes of Health-AARP Diet and Health Study Cohort

✍ Lindsay M. Morton; Sophia S. Wang; Douglas A. Richesson; Arthur Schatzkin; Alber 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 88 KB 👁 1 views

## Abstract Reasons for higher incidence of lymphoid neoplasms among men than women are unknown. Because female sex hormones have immunomodulatory effects, reproductive factors and exogenous hormone use may affect risk for lymphoid malignancies. Previous epidemiologic studies on this topic have yie

Alcohol and endometrial cancer risk in t

Alcohol and endometrial cancer risk in the NIH-AARP diet and health study

✍ Hannah P. Yang; Gretchen L. Gierach; Kim N. Danforth; Mark E. Sherman; Yikyung P 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 144 KB 👁 2 views

## Abstract Previous investigations have provided conflicting results regarding whether alcohol consumption affects endometrial cancer risk, although in many of these studies the highest category of alcohol intake examined was limited. Further, most were unable to resolve how alcohol associations a

Reproductive factors, exogenous hormone

Reproductive factors, exogenous hormone use and bladder cancer risk in a prospective study

✍ Marie M. Cantwell; James V. Lacey Jr.; Catherine Schairer; Arthur Schatzkin; Dom 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 77 KB 👁 2 views

## Abstract Sex is a consistent predictor of bladder cancer: men experience 2–4‐fold higher age‐adjusted rates than women in the U.S. and Europe. The objective of this study was to examine whether hormone‐related factors are associated with bladder cancer in women. We examined parity, age at menarc

Depression and the subsequent risk of Pa

Depression and the subsequent risk of Parkinson's disease in the NIH-AARP Diet and Health Study

✍ Fang Fang; Qun Xu; Yikyung Park; Xuemei Huang; Albert Hollenbeck; Aaron Blair; A 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 96 KB 👁 2 views

## Abstract We conducted a case‐control study to examine the association between depression and Parkinson's disease (PD). Participants included 992 PD cases diagnosed after 2,000 and 279,958 individuals without PD from the NIH‐AARP Diet and Health Study follow‐up survey. Physician‐diagnosed depress

Physical activity, sedentary behavior, a

Physical activity, sedentary behavior, and endometrial cancer risk in the NIH-AARP Diet and Health Study

✍ Gretchen L. Gierach; Shih-Chen Chang; Louise A. Brinton; James V. Lacey Jr.; Alb 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 116 KB 👁 2 views

## Abstract Consistent with a strong hormonal etiology, endometrial cancer is thought to be influenced by both obesity and physical activity. Although obesity has been consistently related to risk, associations with physical activity have been inconclusive. We examined relationships of activity pat

Dietary nitrate and nitrite and the risk

Dietary nitrate and nitrite and the risk of thyroid cancer in the NIH-AARP Diet and Health Study

✍ Briseis A. Kilfoy; Yawei Zhang; Yikyung Park; Theodore R. Holford; Arthur Schatz 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 369 KB 👁 2 views

## Abstract During the past several decades, an increasing incidence of thyroid cancer has been observed worldwide. Nitrate inhibits iodide uptake by the thyroid, potentially disrupting thyroid function. An increased risk of thyroid cancer associated with nitrate intake was recently reported in a c