Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex
β Scribed by Viken, M K; Blomhoff, A; Olsson, M; Akselsen, H E; Pociot, F; Nerup, J; Kockum, I; Cambon-Thomsen, A; Thorsby, E; Undlien, D E
- Book ID
- 109852880
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 267 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1466-4879
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## Abstract The identification of endogenously produced antigenic peptides presented by MHC class I molecules has opened the way to peptideβbased strategies for CTL induction __in vivo__. Here we demonstrate that the induction __in vivo__ of CTL directed against naturally processed antigens can be
## Background: Recent studies have demonstrated an association of a polymorphic (gct)n triplet repeat in the transmembrane (tm) region of the major histocompatibility complex (mhc) class i chain-related gene a (mica), one of the mhc class i chain-related (mic) family members, with some autoimmune d