Reproducibility of TMS—Evoked EEG responses

✍ Scribed by Pantelis Lioumis; Dubravko Kičić; Petri Savolainen; Jyrki P. Mäkelä; Seppo Kähkönen

• Book ID: 102846071
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 542 KB
• Volume: 30
• Category: Article
• ISSN: 1065-9471
• DOI: 10.1002/hbm.20608

✦ Synopsis

Abstract

Navigated transcranial magnetic stimulation combined with electroencephalography (nTMS‐EEG), allows noninvasive studies of cortical excitability and connectivity in humans. We investigated the reproducibility of nTMS‐EEG in seven healthy subjects by repeating left motor and prefrontal cortical stimulation with a 1‐week interval. TMS was applied at three intensities: 90, 100, and 110% of subjects' motor threshold (MT). The TMS‐compatible neuronavigation system guaranteed precise repositioning of the stimulation coil. The responses were recorded by a 60‐channel whole head TMS‐compatible EEG amplifier. A high overall reproducibility (r > 0.80) was evident in nTMS‐EEG responses over both hemispheres for both motor and prefrontal cortical stimulation. The results suggest that nTMS‐EEG is a reliable tool for studies investigating cortical excitability changes in the test‐retest designs. Hum Brain Mapp, 2009. © 2008 Wiley‐Liss, Inc.