Reproducibility of the Dose-Response Curve of Steroid-Induced Cleft Palate in Mice
โ Scribed by Stan C. Freni; Mehdi Razzaghi; Gary E. Moore
- Book ID
- 109156958
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 395 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1573-9147
No coin nor oath required. For personal study only.
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Retinoic acid (RA) plays an important role in embryogenesis, by regulating morphogenesis, cell proliferation, differentiation, and extracellular matrix production. RA exposure on gestational day (GD) 12 in CD-1 mice results in delayed palatal shelf elevation and subsequent clefts in the secondary pa
## Background: 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (tcdd) can cause a high percentage of cleft palate in fetuses when administered during organogenesis in certain strains of mice including the c57bl/6j. in this study, vitamin b(6) (b(6)) was tested for antiteratogenic effects on tcdd-induced cle