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Repression of interferon-γ-induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways

✍ Scribed by Jin-Sun Park; Moon-Sook Woo; So-Young Kim; Won-Ki Kim; Hee-Sun Kim


Book ID
113729671
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
231 KB
Volume
168
Category
Article
ISSN
0165-5728

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## Abstract A proinflammatory cytokine IFN‐γ stimulates microglia in the injured brain; however, signaling pathways for IFN‐γ‐mediated microglia activation are not well characterized. In the present study, a protein kinase C (PKC) activator phorbol 12‐myristate 13‐acetate (PMA) acts in concert with