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Repression of GLUT4 expression by the endoplasmic reticulum stress response in 3T3-L1 adipocytes

✍ Scribed by Ryan S. Miller; Daniel Diaczok; David W. Cooke

Book ID
116295470
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
171 KB
Volume
362
Category
Article
ISSN
0006-291X

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We tested the hypothesis that the constitutive glucose transporter (GLUT1) in 3T3-L1 adipocytes belongs to the family of glucose-regulated proteins which are transcriptionally regulated by glucose deprivation. Using cDNA probes for both GRP78 (BiP) and GLUT1, we show that the level of GRP78 mRNA inc