✦ LIBER ✦

Reporter genes: too much of a good thing?

✍ Scribed by Dr. Bruce E. Torbett

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 46 KB
Volume: 4
Category: Article
ISSN: 1099-498X
DOI: 10.1002/jgm.323

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Advances in viral vector design and identification of new reporter genes have allowed the development of novel delivery systems. In the presence of reporter genes, cellular transduction frequency, expression of the gene of interest and phenotypic effects in cells expressing the gene under study can now be easily monitored both in vitro and in vivo. Moreover, the presence of unique cell markers allows for the enrichment of transduced cells for research studies or patient infusion. The ideal reporter gene product should be biologically inert and not influence the cell population under investigation. Recent reports suggest that reporter gene products may not be biologically benign. Copyright © 2002 John Wiley & Sons, Ltd.

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