Report on the workshop: Von Willebrand factor and thrombotic thrombocytopenic purpura
β Scribed by Joel L. Moake; J. Evan Sadler; Pier Mannucci; Pankaj Ganguly
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 34 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0361-8609
- DOI
- 10.1002/ajh.1163
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π SIMILAR VOLUMES
Extensive microvascular platelet aggregation is characteristic of thrombotic thrombocytopenic purpura (TTP). Previous studies have indicated that abnormalities of von Willebrand factor (vWf) are often present in TTP patient plasma. There has not been previously any direct evidence linking these abno
Thrombotic thrombocytopenic purpura (TTP) is a disorder of systemic platelet aggregation. Evidence has accumulated that the aggregating agonist in TTP of all types is likely to be von Willebrand factor (vWf), especially unusually large vWf multimers derived from endothelial cells. Recent evidence in
## Abstract Decreased von Willebrand factor (VWF)βcleaving protease activity (<5%) has been implicated in patients with congenital thrombotic thrombocytopenic purpuraβhemolytic uremic syndrome (UpshawβSchulman syndrome) and associated with mutations within the __ADAMTS13__ gene. In this report, we
Three patients (one with idiopathic thrombocytopenic purpura [ITP] and two with thrombotic thrombocytopenic purpura [TTP]) were treated with rituximab (anti-CD20 chimeric antibody) at a dose of 325 mg/m 2 administered weekly after they failed standard therapies. The patient with ITP who did not resp