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Reply to the letter to the editor “Classification of thymidylate synthase gene enhancer region polymorphisms”

✍ Scribed by Lisa F. Lincz; Fiona E. Scorgie; Madhu B. Garg; Stephen P. Ackland


Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
46 KB
Volume
121
Category
Article
ISSN
0020-7136

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has