Reply to sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease)

✍ Scribed by M. Pérez-Guillermo; J. Sola-Pérez

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 8 KB
• Volume: 16
• Category: Article
• ISSN: 8755-1039
• DOI: 10.1002/(sici)1097-0339(199703)16:3<285::aid-dc19>3.0.co;2-h

✦ Synopsis

published in Diagnostic Cytopathology concerning the cytologic findings in a case of Rosai-Dorfman disease (RDD) with nodal and nasal involvement. The authors mentioned that there are few reports about cytologic findings of RDD, and they refer to only four articles, dated 1990-1992.

In an issue of Diagnostic Cytopathology published in 1993, we reported on a case of extranodal RDD involving both breasts in a 71-yr-old female diagnosed by fine-needle aspiration (FNA). 2 Our cytologic findings were very similar to those referred to by Alvarez Alegret et al., 1 i.e., poor showing of centroblasts and immunoblasts, frequent plasma cells together with lymphohistiocytic aggregates, numerous histiocytes with broad cytoplasm, and a vesicular nucleus that occasionally showed a prominent nucleolus and slight atypia. Lymphocytophagocytosis (emperipolesis) was seen more easily in Pap-stained smears than in Diff-Quik-stained smears.

We believe that the cytologic pattern of RDD as seen in FNA aspirates is unmistakable, and permits a confident diagnosis of this entity.