✦ LIBER ✦

Reply to Meheus and Union

✍ Scribed by J. G. García Lerma; J. Sequí Navarro

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 39 KB
Volume: 10
Category: Article
ISSN: 0887-8013
DOI: 10.1002/(sici)1098-2825(1996)10:1<58::aid-jcla11>3.0.co;2-p

No coin nor oath required. For personal study only.

✦ Synopsis

The origin of this confusion was the product insert included in the combined RheumELISA system employed by us for the simultaneous detection of anti-Ro/SSA, La/SSB, Sm, and U1 RNP autoantibodies. In the Summary and Explanation section, there was a paragraph that led us to assume that Sm was obtained by recombinant DNA technology: "The RheumELISA System employs recombinant DNA technology to produce purified autoantigens in a solid-phase ELISA microwell format for the detection of specific antinuclear antibodies. This microwell immunoassay system allows for the discrete or simultaneous detection of serum antibodies to Ul-RNP, Sm, SS-A/Ro, and SS-B/La." However, we agree with you that in the product insert of the separately sold RheumELISA System for Sm autoantibody detection, the manufacturer says that the material used is based on purified Sm antigen. Therefore, the strength of agreement obtained in our study is only applicable to purified, but not to recombinant. Sm autoantigen.

📜 SIMILAR VOLUMES

Reply to Lerma et al.

✍ Lydie Meheus; Ann Union 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 55 KB 👁 1 views

## Letter to the Editor As we are involved in the evaluation of recombinant autoantigens, we have read the article by Lerma et al., "Evaluation of Recombinant Ro/SSA, La/SSB, Sm, and U1 RNP Autoantigens in Clinical Diagnosis" with great interest (1). However, there was one particular conclusion i

Reply to Liu and Bilkey's reply

✍ L. Stan Leung; Kevin J. Canning 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 299 KB 👁 1 views

Reply to Nanzer and Coeuret

✍ Paul-Louis Fabre 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 262 KB

too rapidly made. Finally, the cell geometry adopted by the authors was not at all satisfactory from an electrochemical engineering point of view; this type of cell could have affected the results. Jorge 0. Nanzer and Franqois Coeuret UMR CNRS 11'6607 (Nantes) ENSCR -Av. du General Leclerc 35700 Ren

Reply to Bedard and Kandel

✍ Lester J. Layfield; Evelyn V. Gopez 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 348 KB

Reply to Ferbinteanu and Milgram

✍ David Bilkey; Ping Liu 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 19 KB 👁 1 views

Reply to Seller and Bobrow

✍ Verp, Marion S. 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 54 KB

## Letter to the Editor: Reply to Seller and Bobrow To the Editor: Seller and Bobrow are correct regarding the timing of testicular descent in the fetus. However, hydroceles develop not from the testicle, but from the vaginal process which evaginates into the scrotal swelling by the middle of the