Reply to correspondence from Kosztol�nyi and M�hes ?Supernumerary digital flexion creases?
✍ Scribed by Krantz, Ian D. ;Kamath, Binita M.
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 27 KB
- Volume
- 121A
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
✦ Synopsis
The recent correspondence submitted by Kosztola ´nyi and Me ´hes [2003] describing the prevalence of supernumerary and/or absent digital flexion creases amongst a population of 398 Hungarian children with severe mental retardation is a welcome addition to the literature on this subject. Although this population represents a heterogeneous group of etiologies, it is interesting that the prevalence of this minor anomaly is appreciably higher than what was seen in our clinics here at The Children's Hospital of Philadelphia (no supernumerary digital flexion creases identified in 250 children referred for various reasons to the genetics practice of one of the authors (I.D.K.) over the period of 1 year). However, it does appear to be somewhat consistent with other reported rates in the literature (less than 1% of general population with 5th finger supernumerary digital flexion creases [Komatz et al., 1978], and 7-11% of a control population with distal interphalangeal supernumerary digital flexion creases [DeJong and Platou, 1967;Zizmor, 1973]). However, the supernumerary creases described by Kosztola ´nyi and Me ´hes [2003] seem to affect multiple digits and are more pronounced than those reported in the studies of DeJong andPlatou [1967], andZizmor [1973]. It is particularly interesting to note that out of the 13 children with supernumerary digital flexion creases identified in Kosztola ´nyi and Me ´hes [2003] study only 2 (15%) had syndromic diagnoses. It would be of interest to know more details of the clinical and cytogenetic evaluations performed on the other 11 children. The relationship of these minor anomalies to syndromic and nonsyndromic congenital malformations has yet to be fully understood. It is clear that there is a significant genetic component