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Reply to comments on ‘An HPLC method for the measurement of free cortisol/cortisone ratio in human urine’

✍ Scribed by Al Sharef O; Feely J; Scott KR; Kavanagh PV; Sharma SC

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 74 KB
Volume: 21
Category: Article
ISSN: 0269-3879
DOI: 10.1002/bmc.933

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An HPLC method for the determination of

An HPLC method for the determination of the free cortisol/cortisone ratio in human urine

✍ O. Al Sharef; J. Feely; P. V. Kavanagh; K. R. Scott; S. C. Sharma 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 253 KB 👁 2 views

## Abstract The measurement of the urinary free cortisol–cortisone ratio has been reported to be a sensitive indicator of renal 11 __β__‐hydroxysteroid dehydrogenase type 2 (11 __β__‐HSD 2) activity. This converts biologically active cortisol to inactive cortisone. A decrease in its activity (e.g.

Proper assessment of free corticosteroid

Proper assessment of free corticosteroid excretion in human urine depends not only on the use of a reproducible analytical method but also on the attention that urine volume may be an important pre-analytical parameter: a comment on the work of Al Sharef and co-workers

✍ Martin Fenske 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 72 KB 👁 1 views