Reply: The easiest way to improve the outcome of suboptimal liver grafts
โ Scribed by Francesco D'Amico; Alessandro Vitale; Alberto Brolese; Giacomo Zanus; Umberto Cillo
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 48 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1527-6465
- DOI
- 10.1002/lt.21489
No coin nor oath required. For personal study only.
โฆ Synopsis
As observed by Jeon and Ranjan, 1 suboptimal donor livers are an essential resource for liver transplantation (LT) candidates. In our prospective randomized study, 2 the harvesting technique showed a relevant prognostic impact on post-LT outcome when suboptimal livers were used. Observations from Jeon and Ranjan, however, give us the opportunity to further consider our results:
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Livers exposed to warm ischemia (WI) before transplantation are at risk for primary nonfunction (PNF), graft dysfunction, and ischemic biliary strictures, all associated with ischemia/reperfusion injury (IRI). Our multifactorial approach, Leuven drug protocol (LDP), has been shown to reduce these ef