✦ LIBER ✦

Reply: Effect of prophylaxis on fungal infection and costs for high-risk liver transplant recipients

✍ Scribed by Shirish Huprikar

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 43 KB
Volume: 14
Category: Article
ISSN: 1527-6465
DOI: 10.1002/lt.21458

No coin nor oath required. For personal study only.

✦ Synopsis

Prevention of fungal infections following liver transplantation is an important goal, and I appreciate the efforts of Reed et al. 1 to determine the efficacy of prophylactic amphotericin B (AMPH) in high-risk liver transplant recipients. In their study, fungi were isolated from 37 anatomic sites in 31 patients defined to have fungal infections (28 in the no-prophylaxis group and 3 in the AMPH group). The authors concluded that "failure to offer prophylaxis conferred a 4-fold greater risk of fungal infection." However, their definition of fungal infection may have overestimated the number of true fungal infections (particularly in the no-prophylaxis group) by potentially using the isolation of Candida from certain anatomic sites (respiratory, urine, and bile) as the sole criterion for fungal infection.

The authors state that they used the Mycoses Study Group definitions of proven and probable infection 2 and that "respiratory isolates obtained by bronchoscopy

📜 SIMILAR VOLUMES

Effect of prophylaxis on fungal infectio

Effect of prophylaxis on fungal infection and costs for high-risk liver transplant recipients

✍ Alan Reed; Jill Boylston Herndon; Nail Ersoz; Takahisa Fujikawa; Denise Schain; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB 👁 1 views

We sought to determine whether the prophylactic use of amphotericin B products (conventional amphotericin B and liposomal amphotericin B) reduces the incidence of fungal infections in high-risk liver transplant recipients, and if so, whether this lowers the cost of care. The study sample comprised 2

Increased incidence of cytomegalovirus i

Increased incidence of cytomegalovirus infection in high-risk liver transplant recipients receiving valganciclovir prophylaxis versus ganciclovir prophylaxis

✍ Kevin T. Shiley; Leanne B. Gasink; Todd D. Barton; Patrice Pfeiffenberger; Kim M 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 83 KB 👁 1 views

Optimal measures for the prevention of cytomegalovirus (CMV) in high-risk orthotopic liver transplant (OLT) patients are unknown. The charts of high-risk OLT recipients with 12 months of follow-up who were transplanted over a 44-month period were reviewed. The incidence of CMV disease in CMV-seropos

Effect of antibiotic prophylaxis on the

Effect of antibiotic prophylaxis on the risk of surgical site infection in orthotopic liver transplant

✍ Angel Asensio; Antonio Ramos; Valentin Cuervas-Mons; Elisa Cordero; Victor Sánch 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB 👁 1 views

Surgical site infections are common bacterial infections in orthotopic liver transplantation. The purpose of this study was to determine the incidence, timing, location, and risk factors, specifically antibiotic prophylaxis, for surgical site infections. A prospective study was performed that includ