Reply: CAG repeat size in the normal HTT allele and age of onset in Huntington's disease
✍ Scribed by Jan S̆tochl; Jir̆í Klempír̆; Jan Roth
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 307 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Huntington's disease (HD) is caused by the expansion of the number of CAG repeats on the chromosome 4p16.3, which results in elongated glutamine tract of huntingtin. The purpose of this work was to examine the interaction between the normal and mutant alleles of this gene and their effe
## Abstract The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (__HD__) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the