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Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

✍ Scribed by Rita B. Effros; Graham Pawelec

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
702 KB
Volume
18
Category
Article
ISSN
0167-5699

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✦ Synopsis

Extensive in vitro research on fibroblasts has defined numerous genetic and phenotypic changes associated with replicative senescence. Identification of T-cell replicative senescence as a feature of human immunodeficiency virus (HIV) disease and ageing suggests this phenomenon merits more careful consideration by immunologists, especially with regard to chronic infection, memory and adoptive immunotherapy.

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