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Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

✍ Scribed by Franke, Andre; Balschun, Tobias; Karlsen, Tom H; Hedderich, Jürgen; May, Sandra; Lu, Tim; Schuldt, Dörthe; Nikolaus, Susanna; Rosenstiel, Philip; Krawczak, Michael

Book ID: 109914194
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 259 KB
Volume: 40
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng.148

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Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis

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Background: Both ulcerative colitis (UC) and Crohn's disease (CD) have a complex etiology involving multiple genetic and environmental factors. Many genome-wide association studies (GWAS) and subsequent replication studies revealed that both diseases share some of the susceptibility loci; however, c