Replication of hepatic DNA in rats treated with dimethylnitrosamine
β Scribed by S. Rajalakshmi; D.S.R. Sarma
- Book ID
- 113135538
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- English
- Weight
- 602 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0009-2797
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## Abstract Endocrine modulation of DMN carcinogenesis was studied in NZR/Gd rats preconditioned by starving 48 hr and then injected i.p. once with 20 mg DMN/kg. Intact rats developed kidney tumors (44% TBA), most of tubular epithelial type resembling human tumors rather than mesenchymal. Thyroidec
Descending colon is the most unsitive segment of rat intestine and is at least as ynsitive as liver to the carcinogenic effectr of methylazoxymethanol acetate. To determine whether a relationship esistr between tumor induction and level of DNA methylation, we measured the levels of 7-methylguanine i