๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Replication-defective genomic herpes simplex vectors: design and production

โœ Scribed by Edward A Burton; Qing Bai; William F Goins; Joseph C Glorioso

Book ID
104361681
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
203 KB
Volume
13
Category
Article
ISSN
0958-1669

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โœฆ Synopsis

Herpes simplex virus (HSV) may be engineered to produce flexible and efficient gene delivery vectors. Recent advances in vector design and production have built on increasing understanding of the basic biology of HSV to minimise vector toxicity and exploit viral features that give rise to lifelong latent infection in the nervous system. In addition, the emerging picture of viral cell entry has allowed early steps to be taken towards targeting viral entry to predetermined cellular subsets. Recent work has established sound principles for the straightforward production of large-scale pure preparations of vector stocks for clinical applications.

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## Abstract Herpes simplex virus type 1 (HSVโ€1) represents an attractive vehicle for a variety of gene therapy applications. To render this virus safe for clinical use, its cytotoxic genes must be removed without losing its ability to express transgenes efficiently. Our vectors are deleted for the