Replicating Vaccines: A New Generation

✍ Scribed by Gordon Dougan, David Goulding, Lindsay J. Hall (auth.), Philip R. Dormitzer, Christian W. Mandl, Rino Rappuoli (eds.)

• Publisher: Springer Basel
• Year: 2011
• Tongue: English
• Leaves: 449
• Series: Birkhäuser Advances in Infectious Diseases
• Edition: 1
• Category: Library

✦ Synopsis

Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.

✦ Table of Contents

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Live Vaccines and Their Role in Modern Vaccinology....Pages 3-14
Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster Virus....Pages 15-46
Classical Live Viral Vaccines....Pages 47-69
Front Matter....Pages 71-71
Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus....Pages 73-97
Live-Attenuated Shigella Vaccines. Is Encouraging Good Enough?....Pages 99-117
New Generation BCG Vaccines....Pages 119-169
Front Matter....Pages 171-171
Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines....Pages 173-193
Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation....Pages 195-221
An Attenuated HSV-1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell-to-Cell and Neuronal Spread....Pages 223-236
Live Attenuated Vaccines for Respiratory Syncytial Virus....Pages 237-259
Live Attenuated Cholera Vaccines: Flagella and Reactogenicity....Pages 261-281
Front Matter....Pages 283-283
Replication-Defective Herpes Simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors....Pages 285-298
Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines....Pages 299-320
Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines....Pages 321-330
Alphavirus Particle-Based Vaccine Vectors....Pages 331-347
Recombinant, Chimeric, Live, Attenuated Vaccines Against Flaviviruses and Alphaviruses....Pages 349-438
Back Matter....Pages 439-447

✦ Subjects

Medical Microbiology; Vaccine; Immunology; Virology