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Replicate flasks are not necessary for in vitro chromosome-aberration assays in CHO cells

โœ Scribed by Keith A. Soper; Sheila M. Galloway


Book ID
113252973
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
862 KB
Volume
312
Category
Article
ISSN
0165-1161

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## Abstract International guidelines for cytotoxicity limits for the in vitro chromosomal aberration assay require reductions in cell growth of greater than 50%. This sets no upper limit on toxicity and there is concern about the number of false or irrelevant results obtained in the aberration assa