Replacement of the 4′-Hydroxy Group of Amodiaquine and Amopyroquine by Aromatic and Aliphatic Substituents: Synthesis and Antimalarial Activity
✍ Scribed by Emilia Păunescu; Sophie Susplugas; Emmanuelle Boll; Richard Varga; Elisabeth Mouray; Ion Grosu; Philippe Grellier; Patricia Melnyk
- Book ID
- 102805285
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 667 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1860-7179
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Cycloadditions of 3-aryl-l,2.4,5-tetrazines la-o with ethynyltributyltin 5 occur with high regioselectivity to yield 3-aryl-5-tributylstannyl-pyridazines 9-23 in 71-95% yield. Moreover, the stannanes obtained could be utilized as starting materials for the preparation of various 3,5-allsubstituted p
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