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Replacement of Leishmania N-acetylglucosamine-1-phosphate transferase gene requires episomal rescue

โœ Scribed by De-Qiao Chen; Honggang Lu; Kwang-Poo Chang


Book ID
114146676
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
129 KB
Volume
100
Category
Article
ISSN
0166-6851

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Mutational analysis of the GNPTAB gene was performed in 46 apparently unrelated patients with mucolipidosis IIฮฑ/ฮฒ or IIIฮฑ/ฮฒ, characterized by the mistargeting of multiple lysosomal enzymes as a consequence of a UDP-GlcNAc-1-phosphotransferase defect. The GNPTAB mutational spectrum comprised 25 disti