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Repeated DNA sequences in the distal long arm of the human X chromosome

✍ Scribed by U. Müller; U. Tantravahi; A. Monaco; Helene Stroh; L. M. Kunkel; S. A. Latt

Publisher
Springer
Year
1986
Tongue
English
Weight
680 KB
Volume
74
Category
Article
ISSN
0340-6717

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✦ Synopsis

Two DNA probes from within a single large insert from a recombinant phage-DNA library that was constructed from flow-sorted chromosomes enriched for the human X chromosome were shown to hybridize with repeated X-specific and autosomal DNA sequences. The X-chromosomal repeated sequences were assigned to the distal long arm of the X chromosome by both hybrid mapping and in situ hybridization. Fine mapping places these repeats in a region of Xq28 between DX13 (DXS15, in distal Xq28) and factor VIII (F8C, in proximal Xq28). The location of the X-specific repeats makes them potentially useful for future investigations of diseases mapping to the distal long arm of the X chromosome, such as the fragile X syndrome.

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