Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: Clinical and biological results from a prospective multicenter study
✍ Scribed by Adriano Chiò; Gabriele Mora; Vincenzo La Bella; Claudia Caponnetto; Gianluigi Mancardi; Mario Sabatelli; Gabriele Siciliano; Vincenzo Silani; Massimo Corbo; Cristina Moglia; Andrea Calvo; Roberto Mutani; Sergio Rutella; Francesca Gualandi; Mario Melazzini; Rosanna Scimè; Mario Petrini; Paola Bondesan; Silvia Garbelli; Stefania Mantovani; Caterina Bendotti; Corrado Tarella;; the STEMALS Study Group
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 210 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0148-639X
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✦ Synopsis
Abstract
Granulocyte colony‐stimulating factor (G‐CSF) induces a transient mobilization of hematopoietic progenitor cells from bone marrow to peripheral blood. Our aim was to evaluate safety of repeated courses of G‐CSF in patients with amyotrophic lateral sclerosis (ALS), assessing disease progression and changes in chemokine and cytokine levels in serum and cerebrospinal fluid (CSF). Twenty‐four ALS patients entered an open‐label, multicenter trial in which four courses of G‐CSF and mannitol were administered at 3‐month intervals. Levels of G‐CSF were increased after treatment in the serum and CSF. Few and transitory adverse events were observed. No significant reduction of the mean monthly decrease in ALSFRS‐R score and forced vital capacity was observed. A significant reduction in CSF levels of monocyte chemoattractant protein‐1 (MCP‐1) and interleukin‐17 (IL‐17) was observed. G‐CSF treatment was safe and feasible in a multicenter series of ALS patients. A decrease in the CSF levels of proinflammatory cytokines MCP‐1 and IL‐17 was found, indicating a G‐CSF–induced central anti‐inflammatory response. Muscle Nerve 43: 189–195, 2011