Repeated circadian growth hormone, luteinizing hormone, and follicle-stimulating hormone in children: Influence of 9-alpha-fluorohydrocortisone
✍ Scribed by D. Schönberg; R. Kappler; W. Ilg
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 601 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0340-6997
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✦ Synopsis
Growth hormone (GH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in plasma of 5 children at different pubertal stages and suffering from moderate orthost~tic complaints, were measured by radioimmunoassay (RIA). Parameters for secretory capacity were arginine loading and circadian hormonal patterns in hourly intervals from 8 a.m. to 8 p.m. and in half-hourly intervals from 8 p.m. to 8 a.m. before and after 6 weeks treatment with 9-aIpha-fluorohydrocortisone (9-alpha-F, Astonin-H, Fa. Merck, Darmstadt, 0.1--0.2 mg/day). Plasma GH during arginine tests and in circadian levels remained unchanged, but circadian LH showed a consistent slight rise in all children.
With pubertal development, magnitude and timing of GH peaks increased in boys, and rather decreased in the two girls toward late puberty. Episodic fluctuation of LH and FSH were more marked during sleep, and increased in the three boys as puberty advanced. Similar intraindividual patterns for GH and LH, but not for FStt were noted in 4 children. Timing of GH and LH peaks appeared to be correlated. An intrinsic hereditary long-term regulatory principle is discussed.