Eosinophils are known to be present in the airways of allergic asthmatics, and have been suggested to contribute to the pathophysiological changes accompanying this condition, particularly hyperresponsiveness to airway spasmogens. However, a causal relationship between pulmonary eosinophil accumulat
✦ LIBER ✦
Repeated aeroallergen challenge induces lung dysfunction but not bronchial hyperresponsiveness in conscious guinea pigs
✍ Scribed by N. Chand; K. Nolan; W. Diamantis; R. D. Sofia
- Book ID
- 105440241
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1992
- Tongue
- English
- Weight
- 182 KB
- Volume
- 37
- Category
- Article
- ISSN
- 1420-908X
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SUMMARY: We studied the effect of iv administration of leukotriene (LT) \(\mathrm{C}_{4}\) on bronchial responsiveness to histamine and airway wall thickening in guinea-pigs. The infusion of \(3 \mu \mathrm{g} / \mathrm{kg} \mathrm{LTC}\) for \(1 \mathrm{~h}\) induced an increase of the relative thi