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Repair of DNA damage in light sensitive human skin diseases

✍ Scribed by Irene Horkay; L. Varga; P. Tamási; S. Gundy

Publisher
Springer-Verlag
Year
1978
Tongue
English
Weight
972 KB
Volume
263
Category
Article
ISSN
0340-3696

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✦ Synopsis

Repair of UV-light induced DNA damage and changes in the semiconservative DNA synthesis were studied by in vitro autoradiography in the skin of patients with lightdermatoses (polymorphous light eruption, porphyria cutanea tarda, erythropoietic protoporphyria) and xeroderma pigmentosum as well as in that of healthy controls. In polymorphous light eruption the semiconservative DNA replication rate was more intensive in the area of the skin lesions and in the repeated phototest site, the excision repair synthesis appeared to be unaltered. In cutaneous porphyrias a decreased rate of the repair incorporation could be detected. Xeroderma pigmentosum was characterized by a strongly reduced repair synthesis.

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