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Repair of Cisplatin−DNA Adducts by the Mammalian Excision Nuclease †

✍ Scribed by Zamble, Deborah B.; Mu, David; Reardon, Joyce T.; Sancar, Aziz; Lippard, Stephen J.


Book ID
127209605
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
562 KB
Volume
35
Category
Article
ISSN
0006-2960

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## Abstract Human ovarian carcinoma exhibits a spectrum of responses to treatment with cisplatin, ranging from marked sensitivity to relative resistance. Variations in the efficiency with which cells repair cisplatin‐DNA adducts may in part determine cisplatin sensitivity. We have investigated the