Repair of calvarial defects in rats by prefabricated, degradable, long fibre composite implants

✍ Scribed by C. A. Scotchford; M. Shataheri; P.-S. Chen; M. Evans; A. J. Parsons; G. A. Aitchison; C. Efeoglu; J. L. Burke; A. Vikram; S. E. Fisher; C. D. Rudd

• Book ID: 102873714
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 940 KB
• Volume: 96A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.32977

✦ Synopsis

Abstract

We report results from an initial small animal study designed to provide information on the biocompatibility of a novel biodegradable composite designed for craniomaxillofacial reconstruction. Rat calvarium was chosen as a clinically analogous model, which allowed comparison between experimental groups (PCL alone, PCL/phosphate glass, or PCL/bioglass implants) and control groups (empty defects or bone grafted defects). All animals recovered well from surgery and no clinical complications were observed. Histological assessment indicated a lack of inflammatory response. The amount of new bone formation at the dural aspect of the implant was statistically significantly higher in the PCL/phosphate glass group than the other experimental groups. This study confirms, in a clinically analogous model, the promise of the novel PCL/phosphate glass composite material. Work is planned toward manufacturing scale up and clinical trials. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2010.