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Reoxygenation-Induced Mitochondrial Damage is Caused by the Ca2-Dependent Mitochondrial Inner Membrane Permeability Transition

โœ Scribed by Takaya Tanaka; Shigeru Hakoda; Naoshi Takeyama


Book ID
114276876
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
121 KB
Volume
25
Category
Article
ISSN
0891-5849

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Previously, we showed that the oxidant chemical, tert-butylhydroperoxide (t-BuOOH), induces a mitochondrial permeability transition (MPT) in intact hepatocytes, causing lethal cell injury. Here, we investigated the role of mitochondrial free Ca2+ in t-BuOOH cytotoxicity to 1-day-cultured rat hepatoc