𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Renin-angiotensin system genes in kidney development

✍ Scribed by Harris, J. Mansel; Gomez, R. Ariel

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
803 KB
Volume
39
Category
Article
ISSN
1059-910X

No coin nor oath required. For personal study only.

✦ Synopsis

The renin-angiotensin system (RAS) plays a key role in cardiovascular homeostasis through the interactions of angiotensin II with its receptors. All components of the RAS are developmentally regulated in the kidney. The functions of the system in the maturing kidney overlap those of the adult, but higher levels of expression and novel locations of expression in the fetus suggest that the RAS has alternate functions as well. Increasing evidence suggests that the RAS may regulate renal growth and development by initiating a complex cascade of events, involving growth factors and proto-oncogenes and other unidentified factors. These same cascades may also be important in renal disease states. Recent advances in the field of molecular and cell biology are providing new tools and strategies to elucidate the intimate mechanisms whereby the RAS regulates growth processes and disease states.

📜 SIMILAR VOLUMES

Renin-angiotensin system in elasmobranch
Renin-angiotensin system in elasmobranch fish: A review
✍ Hazon, N.; Tierney, M.L.; Takei, Y. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB

The renin-angiotensin system (RAS) has been identified recently in elasmobranch fish, and the structure of angiotensin II (ANG II) is unusual ([Asp 1 ,Pro 3 ,Ile 5 ]-ANG II) compared to other vertebrates. Receptors for ANG II have been identified in blood vessels and in a variety of osmoregulatory t

Renin-angiotensin system inhibitors, ang
Renin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer : The Rotterdam Study
✍ Ronald van der Knaap; Claire Siemes; Jan-Willem W. Coebergh; Cornelia M. van Dui 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB

## Abstract ## BACKGROUND. Angiotensin I‐converting enzyme (ACE) inhibitors, angiotensin II antagonists, and the ACE insertion/deletion (I/D) gene polymorphism all influence serum angiotensin II action. Because angiotensin II levels have been associated with cancer, the objective of the current ep

Gene targeting in kidney development
Gene targeting in kidney development
✍ Kreidberg, Jordan A. 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 909 KB

Cancer and development are conceptually related because tumor formation in many cases results from the aberrant expression of a developmental program. This is certainly true of Wilms' tumors, which display a range of phenotypes resembling various stages of kidney development. WT1 has been identified