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RENAL TUBULAR CELL NECROSIS AND APOPTOSIS IN TRANSPLANTED KIDNEYS

✍ Scribed by E. Toronyi; R. Lord; I.D. Bowen; F. Perner; B. Szende

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
361 KB
Volume
25
Category
Article
ISSN
1065-6995

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✦ Synopsis

Renal wedge biopsies were taken from donors' kidneys immediately at the end of cold ischaemia and 30 min after transplantation in 11 cases. Five renal grafts showed immediate and six showed delayed renal function clinically. The ratio of apoptotic and necrotic renal tubular cells and Ki67 activity was determined in both biopsies. Necrotic and apoptotic as well as proliferating renal tubular cells were seen in all samples. Both apoptotic and proliferative activity was decreased in samples taken 30 min after transplantation in cases of immediate renal function compared to the samples taken before transplantation. This phenomenon was not observed in cases of delayed renal function.

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## Abstract ## BACKGROUND The 10‐year risk of developing a solid malignancy is 20% for kidney transplant recipients. The goal of the current study was to investigate the epidemiology and the diagnostic and prognostic parameters associated with de novo malignancies of the native kidney among transp