Renal oncocytoma with t(5;12;11), der(1)t(1;8) and add(19): “true” oncocytoma or chromophobe adenoma?
✍ Scribed by T. Dijkhuizen; E. van den Berg; S. Störkel; B. de Vries; A.Y. van der Veen; M. Wilbrink; A. Geurts van Kessel; B. de Jong
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- French
- Weight
- 364 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Renal oncocytomas reveal a considerable (cyto)genetic heterogeneity. At least 2 genetic subsets are currently recognized, characterized by (1) translocations involving breakpoint 11q13 and (2) the combined loss of chromosomes 1 and X/Y. We present a case of oncocytoma revealing a 3-way translocation involving breakpoint 11q13, a der (1)t(1;8) and an add(19). The der(1) resulted in loss of chromosome 1 sequences. Using fluorescence in situ hybridization, the 11q13 breakpoint of the present case proved to be slightly different from the one observed previously in 3 cases of renal oncocytoma. Whether the 11q13 breakpoint observed in our case resides in or near another gene remains to be elucidated. Int.