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Renal medullary Na-K-ATPase and hypoxic injury in perfused rat kidneys

✍ Scribed by Epstein, Franklyn H; Silva, Patricio; Spokes, Katherine; Brezis, Mayer; Rosen, Seymour

Book ID
109881362
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
416 KB
Volume
36
Category
Article
ISSN
0085-2538

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Hypoxic injury to medullary thick ascend
Hypoxic injury to medullary thick ascending limbs in perfused rat kidneys: Reversible and irreversible phases
✍ Brezis, M. ;Kopolovic, J. ;Rosen, S. 📂 Article 📅 1988 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 773 KB

The tubular epithelial cells located in the renal medulla are normally working in a hypoxic milieu. In isolated rat kidneys perfused with a cell-free medium, the medullary thick ascending limbs of Henle's loop are selectively and reproducibly injured by the imbalance between oxygen demand and supply