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Renal expression of endothelial and inducible nitric oxide synthase, and formation of peroxynitrite-modified proteins and reactive oxygen species in Wegener's granulomatosis

✍ Scribed by Peter Heeringa; Marc Bijl; Alie de Jager-Krikken; Andre Zandvoort; Gerard Dijkstra; Han Moshage; Jan W. Cohen Tervaert; Anton T. M. G. Tiebosch; Cees G. M. Kallenberg; Harry van Goor

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 502 KB
Volume: 193
Category: Article
ISSN: 0022-3417
DOI: 10.1002/1096-9896(2000)9999:9999<::aid-path782>3.0.co;2-s

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## Nitric oxide (NO) and reactive oxygen species (ROS) are important mediators in the pathogenesis of inflammatory bowel disease (IBD). NO in IBD can be either harmful or protective. NO can react with superoxide anions (O 2 • ), yielding the toxic oxidizing agent peroxynitrite (ONOO ). Peroxynitri