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Renal excretion of metolazone, a new diuretic

✍ Scribed by E. J. BELAIR; A. I. COHEN; J. YELNOSKY


Book ID
117956294
Publisher
Nature Publishing Group
Year
1972
Tongue
English
Weight
404 KB
Volume
45
Category
Article
ISSN
0007-1188

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Characterization of renal excretion mech
✍ Tomohiro Nishimura; Yukio Kato; Yoshimichi Sai; Takuo Ogihara; Akira Tsuji πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 145 KB

M17055 was developed as a novel diuretic that inhibits both Na ΓΎ , K ΓΎ , and 2Cl Γ€ cotransport at the thick ascending Henle's loop and Na ΓΎ reuptake at the distal tubule. It is secreted at the renal proximal tubules. The purpose of the present study was to characterize the renal excretion mechanism