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Renal excretion of clofarabine: Assessment of dose-linearity and role of renal transport systems on drug excretion

✍ Scribed by Antoinette D. Ajavon; Peter L. Bonate; David R. Taft

Book ID
113592290
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
256 KB
Volume
40
Category
Article
ISSN
0928-0987

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The excretion of emtricitabine (FTC) was characterized using isolated perfused rat kidney (IPK) model. Studies were performed to assess the dose-linearity of FTC excretion, to evaluate the effect of inhibitors of organic anion (probenecid, PBC), organic cation (tetraethylammonium, TEA; cimetidine, C