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Renal excretion of apricitabine in rats: ex vivo and in vivo studies

โœ Scribed by Mariana Babayeva; Susan Cox; Michael P. White; David R. Taft

Book ID
107697987
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
248 KB
Volume
36
Category
Article
ISSN
0378-7966

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The potential interaction between the nucleoside analog emtricitabine (FTC) and trimethoprim (TMP) was assessed in the isolated perfused rat kidney (IPK) model and in vivo in rats. IPK experiments were performed with FTC alone (2 mg/mL) and in the presence of increasing concentrations of TMP (1-10 m